Publication List

2024

• Development of a deep-learning model tailored for HER2 detection in breast cancer to aid pathologists in interpreting HER2-low cases Bannier, P.-A., Broeckx, G., Herpin, L., Dubois, R., Van Praet, L., Maussion, C., Deman, F., Amonoo, E., Mera, A., Timbres, J., Gillett, C., Sawyer, E., Gazinska, P., Ziolkowski, P., Lacroix-Triki, M., Salgado, R. & Irshad, S., 1 Sept 2024, In: Histopathology. 85, 3, p. 478-488 11 p.

2023

• Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes

  Graham, R., Gazinska, P., Zhang, B., Khiabany, A., Sinha, S., Alaguthurai, T., Flores-Borja, F., Vicencio, J., Beuron, F., Roxanis, I., Matkowski, R., Liam-Or, R., Tutt, A., Ng, T., Al-Jamal, K. T., Zhou, Y. & Irshad, S., 2023, In: Frontiers in Immunology. 14, 1204224.

2022

• BNT162b2 COVID-19 and ChAdOx1 nCoV-19 vaccination in patients with myelodysplastic syndromes

  Abdul-Jawad, S., Beatson, R., Lechmere, T., Graham, R., Alaguthurai, T., Graham, C., Vidler, J., Kulasekararaj, A., Patten, P. E., Doores, K. J. & Irshad, S., May 2022, In: Haematologica. 107, 5, p. 1181-1184 4 p.

• Boosting of Waned Humoral and Cellular Responses to SARS-CoV-2 Variants of Concern Among Patients with Cancer

  McKenzie, D. R., Graham, R., Lechmere, T., Domingo-Vila, C., Alaguthurai, T., Arman, C., Pollock, E., Gousis, C., Kakkassery, H., Carpenter, E., Kurshan, A., Vidler, J., Kulasekararaj, A., Patten, P., North, B. V., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., 17 Nov 2022, In: Cancer research communications. 2, 11, p. 1449-1461 13 p.

• Boosting of Waned Humoral and Cellular Responses to SARS-CoV-2 Variants of Concern Among Patients with Cancer

  McKenzie, D. R., Graham, R., Lechmere, T., Domingo-Vila, C., Alaguthurai, T., Arman, C., Pollock, E., Gousis, C., Kakkassery, H., Carpenter, E., Kurshan, A., Vidler, J., Kulasekararaj, A., Patten, P., North, B. V., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., 2022, In: Cancer research communications. 2, 11, p. 1449-1461 13 p.

• COVID-19 vaccination in patients with cancer, a rapid review

  on behalf of the Cancer and COVID-19 Global Taskforce, 2022, In: ecancermedicalscience. 16, 1355.

• Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

  NeST Study Research Collaborative , 16 Aug 2022, In: The British journal of surgery. 109, 9, p. 800-803 4 p.

• Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers

  Gazinska, P., Milton, C., Iacovacci, J., Ward, J., Buus, R., Alaguthurai, T., Graham, R., Akarca, A., Lips, E., Naidoo, K., Wesseling, J., Marafioti, T., Cheang, M., Gillett, C., Wu, Y., Khan, A., Melcher, A., Salgado, R., Dowsett, M. & Tutt, A. & 3 others, Roxanis, I., Haider, S. & Irshad, S., 14 Oct 2022, In: Clinical Cancer Research. 28, 20, p. 4494-4508 15 p.

• Immunogenicity of SARS-CoV-2 vaccines in patients with cancer

  Kakkassery, H., Carpenter, E., Patten, P. E. M. & Irshad, S., Dec 2022, In: TRENDS IN MOLECULAR MEDICINE. 28, 12, p. 1082-1099 18 p.

• Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

  International Immuno-Oncology Biomarker Working Group, Dec 2022, In: npj Breast Cancer. 6, 1, 16.

2021

• Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients

  Abdul-Jawad, S., Baù, L., Alaguthurai, T., Del Molino Del Barrio, I., Laing, A. G., Hayday, T. S., Monin, L., Muñoz-Ruiz, M., McDonald, L., Francos Quijorna, I., McKenzie, D., Davis, R., Lorenc, A., Chan, J. N. E., Ryan, S., Bugallo-Blanco, E., Yorke, R., Kamdar, S., Fish, M. & Zlatareva, I. & 31 others, Vantourout, P., Jennings, A., Gee, S., Doores, K., Bailey, K., Hazell, S., De Naurois, J., Moss, C., Russell, B., Khan, A. A., Rowley, M., Benjamin, R., Enting, D., Alrifai, D., Wu, Y., Zhou, Y., Barber, P., Ng, T., Spicer, J., Van Hemelrijck, M., Kumar, M., Vidler, J., Lwin, Y., Fields, P., Karagiannis, S. N., Coolen, A. C. C., Rigg, A., Papa, S., Hayday, A. C., Patten, P. E. M. & Irshad, S., 8 Feb 2021, In: CANCER CELL. 39, 2, p. 257-275.e6

• COVID-19 Risk Factors for Cancer Patients: A First Report with Comparator Data from COVID-19 Negative Cancer Patients

  Russell, B., Moss, C. L., Palmer, K., Sylva, R., D'Souza, A., Wylie, H., Haire, A., Cahill, F., Steel, R., Hoyes, A., Wilson, I., Macneil, A., Shifa, B., Monroy-Iglesias, M. J., Papa, S., Irshad, S., Ross, P., Spicer, J., Kordasti, S. & Crawley, D. & 12 others, Zaki, K., Sita-Lumsden, A., Josephs, D., Enting, D., Swampillai, A., Sawyer, E., Fields, P., Wrench, D., Rigg, A., Sullivan, R., Van Hemelrijck, M. & Dolly, S., 19 May 2021, In: Cancers. 13, 10, 2479.

• Covid-19 vaccine safety in cancer patients: A single centre experience

  So, A. C. P., McGrath, H., Ting, J., Srikandarajah, K., Germanou, S., Moss, C., Russell, B., Monroy-Iglesias, M., Dolly, S., Irshad, S., Van Hemelrijck, M. & Enting, D., 2 Jul 2021, In: Cancers. 13, 14, 3573.

• Humoral and cellular immunity to delayed second dose of SARS-CoV-2 BNT162b2 mRNA vaccination in patients with cancer

  McKenzie, D. R., Muñoz-Ruiz, M., Monin, L., Alaguthurai, T., Lechmere, T., Abdul-Jawad, S., Graham, C., Pollock, E., Graham, R., Sychowska, K., Seow, J., Tremain, C., Gousis, C., Domingo-Vila, C., Cooper, J., Vidler, J., Owczarczyk, K., Swampillai, A., Kristeleit, H. & Malim, M. H. & 8 others, Fields, P., Patten, P. E. M., Papa, S., North, B. V., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., 8 Nov 2021, In: CANCER CELL. 39, 11, p. 1445-1447 3 p.

• Lymph Node Immune Profiles as Predictive Biomarkers for Immune Checkpoint Inhibitor Response

  Goode, E. F., Roussos Torres, E. T. & Irshad, S., 24 May 2021, In: Frontiers in Molecular Biosciences. 8, 674558.

• Risk of COVID-19 death in cancer patients: an analysis from Guy's Cancer Centre and King's College Hospital in London

  Guy’s Cancer Real World Evidence, 28 Sept 2021, In: British journal of cancer. 125, 7, p. 939-947 9 p.

• Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study

  Monin, L., Laing, A. G., Muñoz-Ruiz, M., McKenzie, D. R., Del Molino Del Barrio, I., Alaguthurai, T., Domingo-Vila, C., Hayday, T. S., Graham, C., Seow, J., Abdul-Jawad, S., Kamdar, S., Harvey-Jones, E., Graham, R., Cooper, J., Khan, M., Vidler, J., Kakkassery, H., Sinha, S. & Davis, R. & 24 others, Dupont, L., Francos Quijorna, I., O'Brien-Gore, C., Lee, P. L., Eum, J., Conde Poole, M., Joseph, M., Davies, D., Wu, Y., Swampillai, A., North, B. V., Montes, A., Harries, M., Rigg, A., Spicer, J., Malim, M. H., Fields, P., Patten, P., Di Rosa, F., Papa, S., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., Jun 2021, In: The Lancet Oncology. 22, 6, p. 765-778 14 p.

• The NeST (Neoadjuvant systemic therapy in breast cancer) study: National Practice Questionnaire of United Kingdom multi-disciplinary decision making

  on behalf of the NeST Study Research Collaborative, Dec 2021, In: BMC Cancer. 21, 1, 90.

• Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes In Triple-Negative Breast Cancer

  Harris, R. J., Cheung, A., Ng, J. C. F., Laddach, R., Chenoweth, A. M., Crescioli, S., Fittall, M., Dominguez-Rodriguez, D., Roberts, J., Levi, D., Liu, F., Alberts, E., Quist, J., Santaolalla, A., Pinder, S. E., Gillett, C., Hammar, N., Irshad, S., van Hemelrijck, M. & Dunn-Walters, D. K. & 7 others, Fraternali, F., Spicer, J. F., Lacy, K. E., Tsoka, S., Grigoriadis, A., Tutt, A. N. J. & Karagiannis, S. N., 15 Aug 2021, In: Cancer Research. 81, 16, p. 4290-4304 15 p.

2020

• Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

  International Immuno-Oncology Biomarker Working Group, 1 Dec 2020, In: npj Breast Cancer. 6, 1, 15.

• Association Between Vitamin D and Novel SARS-CoV-2 Respiratory Dysfunction – A Scoping Review of Current Evidence and Its Implication for COVID-19 Pandemic

  Santaolalla, A., Beckmann, K., Kibaru, J., Josephs, D., Van Hemelrijck, M. & Irshad, S., 26 Nov 2020, In: Frontiers in Physiology. 11, 564387.

• Clinico-pathologic features, treatment and outcomes of breast cancer during pregnancy or the post-partum period

  O’Sullivan, C. C., Irshad, S., Wang, Z., Tang, Z., Umbricht, C., Rosner, G. L., Christianson, M. S., Stearns, V. & Smith, K. L., 1 Apr 2020, In: Breast Cancer Research and Treatment. 180, 3, p. 695-706 12 p.

• Factors Affecting COVID-19 Outcomes in Cancer Patients: A First Report From Guy's Cancer Center in London

  Russell, B., Moss, C., Papa, S., Irshad, S., Ross, P., Spicer, J., Kordasti, S., Crawley, D., Wylie, H., Cahill, F., Haire, A., Zaki, K., Rahman, F., Sita-Lumsden, A., Josephs, D., Enting, D., Lei, M., Ghosh, S., Harrison, C. & Swampillai, A. & 14 others, Sawyer, E., D'Souza, A., Gomberg, S., Fields, P., Wrench, D., Raj, K., Gleeson, M., Bailey, K., Dillon, R., Streetly, M., Rigg, A., Sullivan, R., Dolly, S. & Van Hemelrijck, M., 22 Jul 2020, In: Frontiers in oncology. 26, 18, 1279.

• Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

  the International Immuno-Oncology Biomarker Working Group, 1 Dec 2020, In: npj Breast Cancer. 6, 1, 17.

• Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer

  An, Z., Flores-Borja, F., Irshad, S., Deng, J. & Ng, T., 4 Feb 2020, In: Frontiers in Immunology. 10, 3111.

2019

• The NeST (neoadjuvant systemic therapy in breast cancer) study – Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer

  Irwin, G. W., Bannon, F., Coles, C. E., Copson, E., Cutress, R. I., Dave, R. V., Grayson, M., Holcombe, C., Irshad, S., O'Brien, C., O'Connell, R. L., Palmieri, C., Shaaban, A. M., Sharma, N., Singh, J., Whitehead, I., Potter, S. & McIntosh, S. A., 1 Jan 2019, In: International Journal of Surgery Protocols. 18, p. 5-11 7 p.

• AllergoOncology: Opposite Outcomes of Immune Tolerance in Allergy and Cancer

  Jensen-Jarolim, E., Bax, H. J., Bianchini, R., Crescioli, S., Daniels-Wells, T. R., Dombrowicz, D., Fiebiger, E., Gould, H. J., Irshad, S., Janda, J., Josephs, D. H., Levi-Schaffer, F., O Mahony, L., Pellizzari, G., Penichet, M. L., Redegeld, F., Roth-Walter, F., Singer, J., Untersmayr, E. & Vangelista, L. & 1 others, Karagiannis, S. N., Feb 2018, In: Allergy. 73, 2, p. 328–340

2018

• Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node-positive breast cancers

  Grigoriadis, A., Gazinska, P., Pai, T., Irshad, S., Wu, Y., Millis, R. R., Naidoo, K., Owen, J. E., Gillett, C. E., Tutt, A. N. J., Coolen, A. & Pinder, S. E., 24 Jan 2018, In: The journal of pathology. Clinical research. 4, 1, p. 39-54

2017

• A phase I study of afatinib combined with paclitaxel and bevacizumab in patients with advanced solid tumors

  Spicer, J., Irshad, S., Ang, J. E., Enting, D., Kristeleit, R., Uttenreuther-Fischer, M., Pemberton, K., Pelling, K., Schnell, D. & de Bono, J., Jan 2017, In: Cancer Chemotherapy and Pharmacology. 79, 1, p. 17-27 11 p.

• Immune-stroma-histological (ISH)-risk score identifies low-risk group within LN-positive breast cancers

  Grigoriadis, A., Gazinska, P., Pinder, S., Pai, T., Irshad, S., Wu, Y., Gillett, C. E., Tutt, A. N. & Coolen, A. C. C., 1 Oct 2017, In: Annals of oncology : official journal of the European Society for Medical Oncology. 28, p. vii27-vii28

• RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers

  Irshad, S., Flores-Borja, F., Lawler, K., Monypenny, J., Evans, R., Male, V., Gordon, P., Cheung, A., Gazinska, P., Noor, F., Wong, F., Grigoriadis, A., Fruhwirth, G. O., Barber, P. R., Woodman, N., Patel, D., Rodriguez-Justo, M., Owen, J., Martin, S. G. & Sarah, E. P. & 13 others, Cheryl, E. G., Poland, S. P., Ameer-Beg, S., McCaughan, F., Carlin, L. M., Hasan, U., Withers, D. R., Lane, P., Vojnovic, B., Quezada, S. A., Ellis, P., Tutt, A. N. J. & Ng, T., 1 Mar 2017, In: Cancer Research. 77, 5, p. 1083-1096 14 p.

2016

• Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

  Flores-Borja, F., Irshad, S., Gordon, P. R., Wong, S. C. F., Sheriff, I., Tutt, A. N. J. & Ng, T.T.-C., 2016, In: Journal of Immunology Research.

2014

• Antiangiogenic therapy: Patient selection and clinical outcomes

  Irshad, S., Tutt, A. & Ellis, P., 1 Feb 2014, Personalized Management of Breast Cancer. FUTURE MEDICINE LTD, p. 81-98 18 p.

• Assessment of microtubule-associated protein (MAP)-Tau expression as a predictive and prognostic marker in TACT: a trial assessing substitution of sequential docetaxel for FEC as adjuvant chemotherapy for early breast cancer

  Irshad, S., Gillett, C., Pinder, S. E., A'Hern, R. P., Dowsett, M., Ellis, I. O., Bartlett, J. M. S., Bliss, J. M., Hanby, A., Johnston, S., Barrett-Lee, P., Ellis, P. & Tutt, A., Apr 2014, In: Breast Cancer Research and Treatment. 144, 2, p. 331-341 11 p.

• Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers

  Watkins, J., Irshad, S., Grigoriadis, A. & Tutt, A., 3 Jun 2014, In: Breast Cancer Research. 16, 11 p., 211.

• Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients

  Weitsman, G., Lawler, K., Kelleher, M. T., Barrett, J., Barber, P. R., Shamil, E., Festy, F., Patel, G., Fruhwirth, G. O., Huang, L., Tullis, I. D. C., Woodman, N., Ofo, E., Ameer-Beg, S. M., Irshad, S., Condeelis, J., Gillett, C. E., Ellis, P. A., Vojnovic, B. & Coolen, A. C. C. & 1 others, Ng, T., Dec 2014, In: Biochemical Society Transactions. 42, 6, p. 1498-1505 8 p.

2013

• BRCA1 mutations and luminal-basal transformation

  Ng, T., Irshad, S. & Stebbing, J., 30 May 2013, In: Oncogene. 32, 22, p. 2712-2714 3 p.

• Use of Live In-Vivo Lymphatic Imaging Techniques to Study the Effects of Immune Cell Interactions in a Syngeneic Mouse Model of Breast Cancer

  Irshad, S., Flores-Borja, F. F., Evans, R., Fruhwirth, G., Pitmilly, J. M., Poland, S., Ameer-Beg, S., Tutt, A. & Ng, T., May 2013, In: Annals of Oncology. 24, p. iii40

2012

• Profiling the Immune Stromal Interface in Breast Cancer and Its Potential for Clinical Impact

  Irshad, S., Grigoriadis, A., Lawler, K., Ng, T. & Tutt, A., Aug 2012, In: Breast care. 7, 4, p. 273-280 8 p.

2010

• Unilateral Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Multiple Carcinoids Treated with Surgical Resection

  Irshad, S., Mclean, E., Rankin, S., Barrington, S., Santis, G., Spicer, J. & Lang-Lazdunski, L., Jun 2010, In: Journal Of Thoracic Oncology. 5, 6, p. 921-923 3 p.

2002

• Differential expression of beta1 and beta2 integrins and L-selectin on CD4+ and CD8+ T lymphocytes in human blood: comparative analysis between isolated cells, whole blood samples and cryopreserved preparations

  Cavers, M., Afzali, B., Afzali Khoshkbijari, B., Macey, M., McCarthy, D. A., Irshad, S. & Brown, K. A., Jan 2002, In: Clinical and Experimental Immunology. 127, 1, p. 60-5 6 p.